GMC Sierra heavy-duty models are offered in 2500HD (three-quarter ton) and 3500HD (one-ton) models, and are available in Work, SLE and SLT trim. Three cab styles, three cargo box styles and five wheelbase lengths are available. Changes for 2010 are minor and include a pair of new exterior colors, OnStar 8.2 and the inclusion of a USB port on all but the base radio.
| Transmission | MSRP | Engine | City/Hwy MPG | |
|---|---|---|---|---|
| Work Truck | 6 speed automatic | $28,625 | 312-hp / 6.0L 8-cyl | 0/0 |
| SLE | 6 speed automatic | $31,530 | 312-hp / 6.0L 8-cyl | 0/0 |